Cholestasis

Cholestasis is a condition where the flow of bile from the liver is slowed or blocked. This can lead to a buildup of bilirubin, bile acids, and other substances in the liver and bloodstream.

The underlying cause can vary, ranging from gallstones and tumors to infections and drug-induced liver injury.

Symptoms often include jaundice (yellowing of the skin and eyes), dark urine, pale stools, and itching.

Treatment focuses on addressing the cause and managing symptoms. .

Cholestasis meaning with examples

• The patient's bloodwork revealed elevated bilirubin levels, indicating cholestasis, likely caused by a gallstone obstructing the bile duct.
• Chronic cholestasis associated with primary biliary cholangitis can lead to severe liver damage if left untreated.
• Prolonged use of certain medications may induce drug-induced cholestasis, necessitating a review of the patient's current prescriptions.
• Early detection and treatment of cholestasis are crucial to prevent complications like liver cirrhosis and liver failure.
• Infants can sometimes develop neonatal cholestasis, requiring specific diagnostic tests and management strategies.